Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented generation (RAG) has been widely adopted to address these limitations by supplementing model outputs with retrieved evidence. However, whether RAG reliably achieves these goals remains unclear. Here, we present the most comprehensive expert evaluation of RAG in medicine to date. Eighteen medical experts contributed a total of 80,502 annotations, assessing 800 model outputs generated by GPT-4o and Llama-3.1-8B across 200 real-world patient and USMLE-style queries. We systematically decomposed the RAG pipeline into three components: (i) evidence retrieval (relevance of retrieved passages), (ii) evidence selection (accuracy of evidence usage), and (iii) response generation (factuality and completeness of outputs). Contrary to expectation, standard RAG often degraded performance: only 22% of top-16 passages were relevant, evidence selection remained weak (precision 41-43%, recall 27-49%), and factuality and completeness dropped by up to 6% and 5%, respectively, compared with non-RAG variants. Retrieval and evidence selection remain key failure points for the model, contributing to the overall performance drop. We further show that simple yet effective strategies, including evidence filtering and query reformulation, substantially mitigate these issues, improving performance on MedMCQA and MedXpertQA by up to 12% and 8.2%, respectively. These findings call for re-examining RAG's role in medicine and highlight the importance of stage-aware evaluation and deliberate system design for reliable medical LLM applications.

This study examines the performance of today's open-source, locally hosted large-language models (LLMs) in handling complex competitive programming tasks with extended problem descriptions and contexts. Building on the original Framework for AI-driven Code Generation Evaluation (FACE), the authors retrofit the pipeline to work entirely offline through the Ollama runtime, collapsing FACE's sprawling per-problem directory tree into a handful of consolidated JSON files, and adding robust checkpointing so multi-day runs can resume after failures. The enhanced framework generates, submits, and records solutions for the full Kattis corpus of 3,589 problems across eight code-oriented models ranging from 6.7-9 billion parameters. The submission results show that the overall pass@1 accuracy is modest for the local models, with the best models performing at approximately half the acceptance rate of the proprietary models, Gemini 1.5 and ChatGPT-4. These findings expose a persistent gap between private, cost-controlled LLM deployments and state-of-the-art proprietary services, yet also highlight the rapid progress of open models and the practical benefits of an evaluation workflow that organizations can replicate on in-house hardware.

Increasingly multi-purpose AI models, such as cutting-edge large language models or other 'general-purpose AI' (GPAI) models, 'foundation models,' generative AI models, and 'frontier models' (typically all referred to hereafter with the umbrella term 'GPAI/foundation models' except where greater specificity is needed), can provide many beneficial capabilities but also risks of adverse events with profound consequences. This document provides risk-management practices or controls for identifying, analyzing, and mitigating risks of GPAI/foundation models. We intend this document primarily for developers of large-scale, state-of-the-art GPAI/foundation models; others that can benefit from this guidance include downstream developers of end-use applications that build on a GPAI/foundation model. This document facilitates conformity with or use of leading AI risk management-related standards, adapting and building on the generic voluntary guidance in the NIST AI Risk Management Framework and ISO/IEC 23894, with a focus on the unique issues faced by developers of GPAI/foundation models.

Global supply lines have been severely disrupted by the COVID-19 epidemic and the conflict between Russia and Ukraine, which has sharply increased the price of commodities and generated inflation. These incidents highlight how critical it is to improve supply chain resilience (SCRES) in order to fend off unforeseen setbacks. Controlling both internal and external interruptions, such as transportation problems brought on by natural catastrophes and wars, is the responsibility of SCRES. Enhancing resilience in supply chains requires accurate and timely information transfer. Promising answers to these problems can be found in the Metaverse and ChatGPT, two new digital technologies. The Metaverse may imitate real-world situations and offer dynamic, real-time 3D representations of supply chain data by integrating blockchain, IoT, network connection, and computer power.Large-scale natural language processing model ChatGPT improves communication and data translation accuracy and speed. To manage risk and facilitate decision making in Supply Chain management, firms should increase information transmission, Speed and quality. This study aim to show the importance of ChatGPT and Metaverse technologies to improve SCRES, with an emphasis on the most important criteria for SCRES, and maturity factor that can influence directly the SC development.

Interpreting complex neural networks is crucial for understanding their decision-making processes, particularly in applications where transparency and accountability are essential. This proposed method addresses this need by focusing on layer-wise Relevance Propagation (LRP), a technique used in explainable artificial intelligence (XAI) to attribute neural network outputs to input features through backpropagated relevance scores. Existing LRP methods often struggle with precision in evaluating individual neuron contributions. To overcome this limitation, we present a novel approach that improves the parsing of selected neurons during LRP backward propagation, using the Visual Geometry Group 16 (VGG16) architecture as a case study. Our method creates neural network graphs to highlight critical paths and visualizes these paths with heatmaps, optimizing neuron selection through accuracy metrics like Mean Squared Error (MSE) and Symmetric Mean Absolute Percentage Error (SMAPE). Additionally, we utilize a deconvolutional visualization technique to reconstruct feature maps, offering a comprehensive view of the network's inner workings. Extensive experiments demonstrate that our approach enhances interpretability and supports the development of more transparent artificial intelligence (AI) systems for computer vision applications. This advancement has the potential to improve the trustworthiness of AI models in real-world machine vision applications, thereby increasing their reliability and effectiveness.

Generative Adversarial Networks (GANs) have proven to be a powerful tool in generating artistic images, capable of mimicking the styles of renowned painters, such as Claude Monet. This paper introduces a tiered GAN model to progressively refine image quality through a multi-stage process, enhancing the generated images at each step. The model transforms random noise into detailed artistic representations, addressing common challenges such as instability in training, mode collapse, and output quality. This approach combines downsampling and convolutional techniques, enabling the generation of high-quality Monet-style artwork while optimizing computational efficiency. Experimental results demonstrate the architecture's ability to produce foundational artistic structures, though further refinements are necessary for achieving higher levels of realism and fidelity to Monet's style. Future work focuses on improving training methodologies and model complexity to bridge the gap between generated and true artistic images. Additionally, the limitations of traditional GANs in artistic generation are analyzed, and strategies to overcome these shortcomings are proposed.

Object detection is a fundamental task in computer vision and image understanding, with the goal of identifying and localizing objects of interest within an image while assigning them corresponding class labels. Traditional methods, which relied on handcrafted features and shallow models, struggled with complex visual data and showed limited performance. These methods combined low-level features with contextual information and lacked the ability to capture high-level semantics. Deep learning, especially Convolutional Neural Networks (CNNs), addressed these limitations by automatically learning rich, hierarchical features directly from data. These features include both semantic and high-level representations essential for accurate object detection. This paper reviews object detection frameworks, starting with classical computer vision methods. We categorize object detection approaches into two groups: (1) classical computer vision techniques and (2) CNN-based detectors. We compare major CNN models, discussing their strengths and limitations. In conclusion, this review highlights the significant advancements in object detection through deep learning and identifies key areas for further research to improve performance.

Time series models, typically trained on numerical data, are designed to forecast future values. These models often rely on weighted averaging techniques over time intervals. However, real-world time series data is seldom isolated and is frequently influenced by non-numeric factors. For instance, stock price fluctuations are impacted by daily random events in the broader world, with each event exerting a unique influence on price signals. Previously, forecasts in financial markets have been approached in two main ways: either as time-series problems over price sequence or sentiment analysis tasks. The sentiment analysis tasks aim to determine whether news events will have a positive or negative impact on stock prices, often categorizing them into discrete labels. Recognizing the need for a more comprehensive approach to accurately model time series prediction, we propose a collaborative modeling framework that incorporates textual information about relevant events for predictions. Specifically, we leverage the intuition of large language models about future changes to update real number time series predictions. We evaluated the effectiveness of our approach on financial market data.

Selecting language models in business contexts requires a careful analysis of the final financial benefits of the investment. However, the emphasis of academia and industry analysis of LLM is solely on performance. This work introduces a framework to evaluate LLMs, focusing on the earnings and return on investment aspects that should be taken into account in business decision making. We use a decision-theoretic approach to compare the financial impact of different LLMs, considering variables such as the cost per token, the probability of success in the specific task, and the gain and losses associated with LLMs use. The study reveals how the superior accuracy of more expensive models can, under certain conditions, justify a greater investment through more significant earnings but not necessarily a larger RoI. This article provides a framework for companies looking to optimize their technology choices, ensuring that investment in cutting-edge technology aligns with strategic financial objectives. In addition, we discuss how changes in operational variables influence the economics of using LLMs, offering practical insights for enterprise settings, finding that the predicted gain and loss and the different probabilities of success and failure are the variables that most impact the sensitivity of the models.

The article identified 42 cognitive architectures for creating general artificial intelligence (AGI) and proposed a set of interrelated functional blocks that an agent approaching AGI in its capabilities should possess. Since the required set of blocks is not found in any of the existing architectures, the article proposes a new cognitive architecture for intelligent systems approaching AGI in their capabilities. As one of the key solutions within the framework of the architecture, a universal method of knowledge representation is proposed, which allows combining various non-formalized, partially and fully formalized methods of knowledge representation in a single knowledge base, such as texts in natural languages, images, audio and video recordings, graphs, algorithms, databases, neural networks, knowledge graphs, ontologies, frames, essence-property-relation models, production systems, predicate calculus models, conceptual models, and others. To combine and structure various fragments of knowledge, archigraph models are used, constructed as a development of annotated metagraphs. As components, the cognitive architecture being developed includes machine consciousness, machine subconsciousness, blocks of interaction with the external environment, a goal management block, an emotional control system, a block of social interaction, a block of reflection, an ethics block and a worldview block, a learning block, a monitoring block, blocks of statement and solving problems, self-organization and meta learning block.